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The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly

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A sleeve gastrectomy involves the surgical removal of approximately 75–80% of the stomach, leaving a narrow, tube-shaped pouch