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Their baseline butyrate production is often already lower than healthy controls, so even modest glutathione-induced microbiome shifts can push them into symptomatic constipation

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For patients planning multi-year use, reasonable maintenance looks like: Annual reassessment with the prescribing clinician Monitoring for any new skin changes Checking copper status if supplementing high-dose zinc A periodic dermatology visit for anyone on high-concentration topical formulations Liver function panel if using injectable GHK-Cu continuously for more than 12 months (a conservative precaution, not a response to documented risk) FAQ Is GHK-Cu safe long-term